Phenotyping of Sleep Apnea using Computational Modeling and Dynamic Imaging
Dr. Khoo leads a multidisciplinary collaborative effort in the form of the USC Viterbi Center for Sleep Health using Bioengineering (SleepHuB). SleepHuB core investigators include Dr. Krishna Nayak (Electrical & Biomedical Engineering), Dr. Sally Ward (Pediatric Pulmonology & Sleep Disorders, CHLA), Dr. Eric Kezirian (Otolaryngology, Keck School of Medicine), Dr. Tomas Konecny (Cardiology, Keck School of Medicine) and Dr. Terese Hammond (Pulmonary & Critical Care Medicine. Recent work includes an NIH-funded study to delineate various phenotypes of sleep-related breathing disorders in pediatric obesity. Significant progress has been made in developing new polysomnographic techniques for assessing respiratory control during sleep, as well as novel methods for dynamic MR imaging of the upper airway in these subjects in sleep onset.
- Javed A, Kim YC, Khoo M, Ward S, Nayak K. Dynamic 3D MR visualization and detection of upper airway obstruction during sleep using region growing segmentation. IEEE Trans Biomed Eng 63(2):431-437, 2016.
- Wu Z, Chen W, Khoo MC, Davidson Ward SL, Nayak KS. Evaluation of upper airway collapsibility using real-time MRI. J Magn Reson Imaging 44(1):158-167, 2016.
- Nava-Guerra L, Tran WH, Chalacheva P, Loloyan S, Joshi B, Keens TG, Nayak KS, Davidson Ward SL, Khoo MC. Model-based stability assessment of ventilatory control in overweight adolescents with obstructive sleep apnea during NREM sleep. J Appl Physiol 121(1):185-197, 2016.
- Chen W, Gillett E, Khoo MCK, Davidson Ward SL, Nayak KS. Real-time multislice MRI during continuous positive airway pressure reveals upper airway response to pressure change. J Magn Reson Imaging 46(5):1400-1408, 2017.