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Model-based Phenotyping of Sleep Apnea


Phenotyping of Sleep Apnea using Computational Modeling and Dynamic Imaging

Dr. Khoo leads a multidisciplinary collaborative effort in the form of the USC Viterbi Center for Sleep Health using Bioengineering (SleepHuB). SleepHuB core investigators include Dr. Krishna Nayak (Electrical & Biomedical Engineering), Dr. Sally Ward (Pediatric Pulmonology & Sleep Disorders, CHLA), Dr. Eric Kezirian (Otolaryngology, Keck School of Medicine), Dr. Tomas Konecny (Cardiology, Keck School of Medicine) and Dr. Terese Hammond (Pulmonary & Critical Care Medicine. Recent work includes an NIH-funded study to delineate various phenotypes of sleep-related breathing disorders in pediatric obesity. Significant progress has been made in developing new polysomnographic techniques for assessing respiratory control during sleep, as well as novel methods for dynamic MR imaging of the upper airway in these subjects in sleep onset.

Representative publications: