Cardiovascular Autonomic Control in Sleep-Disordered Breathing
It is well recognized now that sleep-disordered breathing plays an independent role in facilitating the development of systemic hypertension, stroke, myocardial infarction and other cardiovascular diseases. The evidence also suggests that autonomic nervous system imbalance plays an important role in the underlying causal mechanisms. Dr. Khoo’s team has made important contributions to the development of model-based techniques for noninvasively assessing the early cardiovascular autonomic effects of obstructive sleep apnea before and during treatment. In more than a dozen scientific papers, they have developed and validated a minimal closed-loop model of cardiovascular variability that allows for the quantification of autonomic impairment in patients with sleep apnea using only daytime cardiorespiratory measurements.
- Belozeroff V, Berry RB, Sassoon CSH, Khoo MCK. Effects of long-term CPAP therapy on autonomic cardiovascular control in obstructive sleep apnea: a closed-loop model. Am J Physiol Heart Circ Physiol 282:H110-H121, 2002.
- Jo JA, Blasi A, Valladares E, Juarez R, Baydur A, Khoo MCK. Model-based assessment of autonomic control in obstructive sleep apnea syndrome during sleep. Am J Respir Crit Care Med, 167, 128-136, 2003.
- Chaicharn J, Lin Z, Chen ML, Ward SLD, Keens TG, Khoo MCK. Model-based assessment of cardiovascular autonomic control in children with obstructive sleep apnea. Sleep 32:927-938, 2009.
- Khoo MCK, Chalacheva P. Model-derived makers of autonomic cardiovascular dysfunction in sleep-disordered breathing. Sleep Med Clin 11:489-501, 2016.