Skip to content

Cardiovascular Control in Sleep-Disordered Breathing

Cardiovascular Autonomic Control in Sleep-Disordered Breathing

It is well recognized now that sleep-disordered breathing plays an independent role in facilitating the development of systemic hypertension, stroke, myocardial infarction and other cardiovascular diseases. The evidence also suggests that autonomic nervous system imbalance plays an important role in the underlying causal mechanisms. Dr. Khoo’s team has made important contributions to the development of model-based techniques for noninvasively assessing the early cardiovascular autonomic effects of obstructive sleep apnea before and during treatment. In more than a dozen scientific papers, they have developed and validated a minimal closed-loop model of cardiovascular variability that allows for the quantification of autonomic impairment in patients with sleep apnea using only daytime cardiorespiratory measurements.

Representative publications: