Physiologically-based Computational Models of Cardiorespiratory and Metabolic Control in Sleep
The dynamic interactions that exist across the respiratory, cardiovascular, sleep regulation and metabolic systems lead to complex behaviors that are difficult to understand. Physiologically-based “structured” models provide the integrative framework that allows hypotheses regarding the underlying mechanisms to be tested against empirical measurements. Dr. Khoo and his team have developed computational models of this kind that enable us to simulate the autonomic and metabolic effects of sleep-related breathing disorders and other cardiovascular abnormalities.
Representative publications:
- Cheng L, Ivanova O, Fan HH, Khoo MCK. An integrative model of respiratory and cardiovascular control in sleep-disordered breathing. Respir Physiol Neurobiol, 174, 4-28, 2010.
- Cheng L, Khoo MCK. Modeling the autonomic and metabolic effects of obstructive sleep apnea: a simulation study. Front. Physiol. 2:111, p. 1-20. doi: 10.3389/fphys.2011.00111, 2012.
- Soleymani S, Khoo MC, Noori S, Seri I. Modeling of neonatal hemodynamics during PDA closure. Conf Proc IEEE Eng Med Biol Soc. 1:1886-1889, 2015.
- Khoo MCK. Physiological Control Systems: Analysis, Simulation and Estimation, 2ndEdition. Wiley/IEEE Press, Piscataway, NJ, 2018.
- Association between REM sleep and obstructive sleep apnea in obese and overweight adolescents. Sever O, Kezirian EJ, Gillett E, Davidson Ward SL, Khoo MCK, Perez IA. Sleep Breath 2018, doi: 10.1007/s11325-018-1768-6.