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Computational Models of Cardiorespiratory and Metabolic Control in Sleep


Physiologically-based Computational Models of Cardiorespiratory and Metabolic Control in Sleep

The dynamic interactions that exist across the respiratory, cardiovascular, sleep regulation and metabolic systems lead to complex behaviors that are difficult to understand. Physiologically-based “structured” models provide the integrative framework that allows hypotheses regarding the underlying mechanisms to be tested against empirical measurements. Dr. Khoo and his team have developed computational models of this kind that enable us to simulate the autonomic and metabolic effects of sleep-related breathing disorders and other cardiovascular abnormalities.

Representative publications: