Skip to content


Physiological Control Systems: Analysis, Simulation, and Estimation 

(published by IEEE Press Series on Biomedical Engineering in 2000) 

written by Michael C. K. Khoo



Bioengineering Approaches to Pulmonary Physiology and Medicine

(published by Plenum Press in 1996)

edited by Michael C.K. Khoo



Belozeroff, V., Berry, R.B. & Khoo, M.C.K. (2003). Model-based assessment of autonomic control in obstructive sleep apnea syndrome.Sleep, 26, 65-73.

Jo, J.A., Blasi, A., Valladares, E., Juarez, R., Baydur, A. & Khoo, M.C.K. (2003). Model-based assessment of autonomic control in obstructive sleep apnea syndrome during sleep.American Journal of Respiratory and Critical Care Medicine, 167, 128-136.

Blasi, A., Jo, J., Valladares, E., Juarez, R., Baydur, A. & Khoo, M.C.K. (2006). Autonomic cardiovascular control following transient arousal from sleep: A time-varying closed-loop model. IEEE Transactions on Biomedical Engineering, 53, 74-82.

Jo, J., Blasi, A., Valladares, E., Juarez, E., Baydur, A. & Khoo, M.C.K. (2007). A nonlinear model of cardiac autonomic control in obstructive sleep apnea syndrome. Annals Biomedical Engineering, 35,1425-1443.

Khoo, M.C.K. (2008).Modeling autonomic control in sleep-disordered breathing.Cardiovascular Engineering, 8, 30-41.

Wang, W., Tretriluxana, S., Redline, S., Surovec, S., Gottlieb, D. & Khoo, M.C.K. (2008). Association of cardiac autonomic function measures with severity of sleep-disordered breathing in a community-based sample.Journal of Sleep Research, 17(3), 251-262. PMCID: PMC2774732

Chaicharn, J., Lin, Z., Chen, M.L., Ward, S.L.D., Keens, T.G. & Khoo, M.C.K. (2009). Model-based assessment of cardiovascular autonomic control in children with obstructive sleep apnea.Sleep, 32, 927-938. PMCID: PMC2706908

Khoo, M.C.K.Quantitative models of periodic breathing and Cheyne-Stokes respiration. In: Sleep Disorders and Cardiovascular and Cerebrovascular Disease, 2nd Edition, eds. T.D. Bradley and J.T. Floras, p.275-301, Lung Biology in Health and Disease Series, Marcel Dekker, New York, 2009.

Cheng, L., Ivanova, O., Fan, H.H. & Khoo, M.C.K. (2010). An integrative model of respiratory and cardiovascular control in sleep-disordered breathing.Respiratory Physiology and Neurobiology, 174, 4-28. PMCID: PMC2965826

Sangkatumvong, S., Khoo, M.C.K., Kato, R., Detterich, J.A., Bush, A., Keens, T.G., Meiselman, H.J., Wood, J.C. & Coates, T.D. (2011). Peripheral vasoconstriction and abnormal parasympathetic response to sighs and transient hypoxia: Could the autonomic nervous system trigger sickle cell crisis?American Journal of Respiratory and Critical Care Medicine, 184(4), 474-481. PMCID: PMC3175540

Cheng, L.M., & Khoo, M.C.K. (2012) Modeling the autonomic and metabolic effects of obstructive sleep apnea: a simulation study.Front Physiol 2:111, p. 1-20. doi: 10.3389/fphys.2011.00111. PMCID: PMC3250672

Lesser DJ, Bhatia R, Tran WH, Oliveira F, Ortega R, Keens TG, Mittelman SM, Khoo MC, & Davidson Ward SL. (2012)  Sleep fragmentation and intermittent hypoxemia associated with decreased insulin sensitivity in obese adolescent Latino males.Pediatr Res 72(3):293-298.

Wang W, Redline SA, & Khoo MC (2012). Autonomic markers of impaired glucose metabolism: Effects of sleep-disordered breathing.J Diabetes Sci Technol 6(5):1-13.

Khoo MC, Blasi A (2013). Sleep-related changes in autonomic control in obstructive sleep apnea: a model-based perspective.Respir Physiol Neurobiol 188(3):267-76. (PMID: 23707878)

Chalacheva P, Thum J, Yokoe T, O'Donnell CP, Khoo MC (2013). Development of autonomic dysfunction with intermittent hypoxia in a lean murine model. Respir Physiol Neurobiol188(2):143-51. (PMID: 23774144)

Khoo MC, Oliveira FM, Cheng L (2013). Understanding the metabolic syndrome: a modeling perspective.IEEE Rev Biomed Eng 6:143-55. (PMID: 23232440)

Kim YC, Lebel RM, Wu Z, Ward SL, Khoo MC, Nayak KS (2014). Real-time 3D magnetic resonance imaging of the pharyngeal airway in sleep apnea.Magn Reson Med 71(4):1501-1510. (PMID: 23788203)

Ward S, Amin R, Arens R, Chen Z, Davis S, Gutmark E, Wong B, Khoo MCK (2014). Pediatric sleep-related breathing disorders: Advances in imaging and computational modeling.IEEE Pulse 5(5):33-39. (PMID: 25437473)

Chalacheva P, Kato R, Sangkatumvong S, Detterich J, Bush A, Wood JC, Meiselman H, Coates TD, Khoo MC (2015). Autonomic responses to cold face stimulation in sickle cell disease: A time-varying model analysis.Physiol Rep, 3 (7), e12463, doi:10.14814/phy2.12463. (PMID: 26177958)

Bhatia R, Lesser DJ, Oliveira FG, Tran WH, Keens TG, Khoo MC, Davidson Ward SL (2015). Body fat composition: A predictive factor for sleep related breathing disorder in obese children.J Clin Sleep Med.Jun 11. pii: jc-00494-14. (PMID: 26094935)