Physiological Modeling of Periodic Breathing, Cheyne-Stokes Respiration and Obstructive Sleep Apnea
Using control theory and computational modeling, Dr. Khoo and colleagues have published several seminal studies to demonstrate the periodic breathing and recurrent apnea are a common manifestation of feedback control instability in the respiratory system. The model analyses of the mechanisms that underlie sleep disordered breathing have had a significant impact on pulmonary sleep physiology and medicine by providing a rational framework with which to approach the treatment of various phenotypes of sleep apnea. Three of his seminal publications in this area have received a combined total of over 950 citations.
- Khoo MCK, Kronauer RE, Strohl KP, Slutsky AS. Factors inducing periodic breathing in humans: a general model. J Appl Physiol: Respirat Environ Exercise Physiol 53(3):644-659, 1982.
- Khoo MCK, Gottschalk A, Pack AI. Sleep-induced periodic breathing and apnea: a theoretical study. J Appl Physiol 70:2014-2024, 1991.
- Khoo MCK. Determinants of ventilatory instability and variability. Respir Physiol 122:167-182, 2000.
- Khoo MCK. Quantitative models of periodic breathing and Cheyne-Stokes respiration. In: Sleep Disorders and Cardiovascular and Cerebrovascular Disease, 2nd Edition, eds. Bradley TD, Floras JT, p.275-301, Lung Biology in Health and Disease Series, Marcel Dekker, New York, 2009.