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Physiological Modeling of Sleep-Disordered Breathing

Physiological Modeling of Periodic Breathing, Cheyne-Stokes Respiration and Obstructive Sleep Apnea

Using control theory and computational modeling, Dr. Khoo and colleagues have published several seminal studies to demonstrate the periodic breathing and recurrent apnea are a common manifestation of feedback control instability in the respiratory system. The model analyses of the mechanisms that underlie sleep disordered breathing have had a significant impact on pulmonary sleep physiology and medicine by providing a rational framework with which to approach the treatment of various phenotypes of sleep apnea. Three of his seminal publications in this area have received a combined total of over 950 citations.

Representative publications: