Phenotyping of Sleep Apnea using Computational Modeling and Dynamic Imaging
Dr. Khoo leads a multidisciplinary collaborative effort in the form of the USC Center for Sleep Health using Bioengineering (SleepHuB). Funded research projects have involved SleepHuB core investigators like Dr. Krishna Nayak (ECE & BME), Dr. Sally Ward (CHLA), Dr. Eric Kezirian (UCLA) and Dr. Karen Lincoln (UCI). Recent work includes NIH-funded projects to delineate various phenotypes of sleep-related breathing disorders in pediatric obesity, Down Syndrome, and adult sleep apnea patients before upper airway surgery.
Representative publications:
- Model-based stability assessment of ventilatory control in overweight adolescents with obstructive sleep apnea during NREM sleep. Nava-Guerra L, Tran WH, Chalacheva P, Loloyan S, Joshi B, Keens TG, Nayak KS, Davidson Ward SL, Khoo MC. J Appl Physiol 121(1):185-197, 2016.
- Real-time multislice MRI during continuous positive airway pressure reveals upper airway response to pressure change. Chen W, Gillett E, Khoo MCK, Davidson Ward SL, Nayak KS. J Magn Reson Imaging 46(5):1400-1408, 2017.
- Upper airway narrowing can occur during central apnea in obese adolescents. Kato R, Kim Y, Joshi B, Loloyan S, Wee CP, Wu Z, Tran W, Keens TG, Khoo MC, Nayak KS, Davidson Ward SL. Ann Am Thorac Soc 15(12):1465-1471, 2018.
- Association between REM sleep and obstructive sleep apnea in obese and overweight adolescents. Sever O, Kezirian EJ, Gillett E, Davidson Ward SL, Khoo MCK, Perez IA. Sleep Breath 2018, doi: 10.1007/s11325-018-1768-6.